Similarity and Dissimilarity between Clinical and Laboratory Findings, Especially Anti-Thyrotropin Receptor Autibody in Ophthalmic Graves' Disease without Persistent Hyperthyroidism and Hyperthyroid Graves' Disease.

Anticardiolipin Antibodies and Immunoglobulin M and A in Graves’ Disease

Background: Graves’ disease is an autoimmune disease, characterized by the presence of antibodies directed to TSH receptor or nearby regions as well as antibodies to double strands DNA (dsDNA) anticardiolipin and nuclear antibodies. This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves’ disease. Patients and methods: Anticardiolipin a...

The diagnostic criteria of Graves' disease and especially the thyrotropin receptor antibody; our own experience.

It is generally accepted that the thyrotropin receptor antibody (TRAb) has a stimulating activity and is the major pathogenic factor in Graves' disease (GD). In spite of that, TRAb is not routinely examined in clinical practice. The aim of this article is to briefly review the subject and suggest protocols for the diagnosis, treatment and follow-up of patients with GD based on our own studies a...

Thyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves’ Disease

Graves' disease (GD) is an organ-specific autoimmune disease, and thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of human TSHR (TSHR-ECD) is shed into the circulation, TSHR-ECD is a preferentially immunogenic portion of TSHR. Both genetic factors and environmental factors contribute to development of GD. Inheritance of human leukocyte ...

Motor neurone disease and hyperthyroid Graves' disease: a chance association?

The presentation of a 56-year-old woman with coexisting hyperthyroid Graves' disease and motor neurone disease is described. Circulating immune complexes were detected in the serum of seven patients with motor neurone disease (five cases) or primary lateral sclerosis (two cases), including a man with insulin-dependent diabetes mellitus.

Hyperthyroidism (Overactive Thyroid) and Graves' Disease (Basedow Disease)